tag:blogger.com,1999:blog-655962722302095847.post1311006153586130581..comments2024-03-29T10:24:53.156+01:00Comments on Epiphany: Sulforaphane (Broccoli) for Cancer, Autism and COPDPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger100125tag:blogger.com,1999:blog-655962722302095847.post-2505398306890733432023-07-06T12:43:35.779+02:002023-07-06T12:43:35.779+02:00(Christine H) I’d very much doubt if there are gen...(Christine H) I’d very much doubt if there are genuine SFN-yielding products that can provide 35 or 50 mg. Are you sure that is not the glucoraphanin content, sometimes described as ‘sulforaphane glucosinolate’? It’s a trap for the unwary and in fact are virtually useless, relying on the low levels of conversion to SFN by the gut microbiome. In people with gut issues, this is most unreliable. For a very young child, I would start with a very small amount (end of a knife-blade) and see if he or she can tolerate that. Gradually increase it over time but 20 mg daily of a genuine quality broccoli sprout supplement. That is about 1-2 grams of the powder. Please weigh it as 1 gram is about 7/8 of a teaspoon. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-34870428675768214582023-07-05T14:37:39.593+02:002023-07-05T14:37:39.593+02:00Angela, most of these products are in a capsule th...Angela, most of these products are in a capsule that you can open. So, you can give as bigger or smaller dose as you want.<br /><br />Try a small dose first to see if there is a negative reaction. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-13072532649142130572023-07-05T12:20:19.264+02:002023-07-05T12:20:19.264+02:00Hi again Peter!
I have found a product in Spain wi...Hi again Peter!<br />I have found a product in Spain with 50mg of sulforaphane. Do you think it is a high dose for a 4 and a half year old child weighing 22kg? I have seen another Solaray brand sulforaphane with 35mg. I am afraid of a bad allergic reaction or other serious symptom. Thank you, I wait for your answer.Angelanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-9385829692975618862023-06-28T12:41:21.545+02:002023-06-28T12:41:21.545+02:00Peter, ChatGPT has no ability to provide anything ...Peter, ChatGPT has no ability to provide anything other than what is available on the internet. It has no ability to think critically about an issue that needs mechanistic understanding. All direct antioxidants, including NAC, will mask the signals cells use to activate their endogenous defences via Nrf2. On the other hand, botanicals like Bacopa monniera do not inhibit Nrf2 and can be taken together. The difference is that Bacopa is a naturally occurring plant whereas NAC at the doses commonly ingested are fr in excess of the modest levels cells synthesize themselves. There is nothing natural about megadoses of lab-synthesized molecules like NAC.Christine Houghtonnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-3803555051558588512023-06-27T16:23:40.543+02:002023-06-27T16:23:40.543+02:00Lisa, better to ask can Baccopa be taken with Broc...Lisa, better to ask can Baccopa be taken with Broccoli?<br /><br />Both Baccopa and Broccoli have multiple beneficial modes of action.<br /><br />Baccopa is a potent antioxidant, like NAC.<br /><br />Our reader Christine firmly believes that the antioxidant NAC will reduce the sulforaphane produced by eating broccoli powder. I did combine both for several years.<br /><br />Today I have been asking ChatGPT several reader's questions and here is what it says on this subject of antioxidant NAC and sulforaphane.<br /><br />N-Acetylcysteine (NAC) is not known to block the production of sulforaphane from broccoli. In fact, there is some evidence to suggest that NAC may even enhance sulforaphane production.<br /><br />NAC is a derivative of the amino acid cysteine and is often used as a dietary supplement due to its antioxidant properties and ability to support glutathione production, which is an important antioxidant in the body. While NAC has various health benefits, there is no direct evidence to suggest that it interferes with sulforaphane production from broccoli.<br /><br />On the contrary, some studies have shown that NAC can increase the levels of glutathione, which can indirectly enhance the formation of sulforaphane. Glutathione acts as a cofactor for myrosinase, the enzyme responsible for converting glucoraphanin into sulforaphane. By supporting glutathione production, NAC may help maintain optimal myrosinase activity and promote sulforaphane production.<br /><br />It's important to note that the effects of NAC on sulforaphane production have been studied mainly in cell cultures or animal models, and more research is needed to fully understand the impact in humans. Additionally, the effects of NAC on sulforaphane may depend on various factors, including concentration, timing, and specific conditions.<br /><br />In summary, there is no evidence to suggest that NAC blocks the production of sulforaphane from broccoli. While more research is needed, NAC may even have the potential to enhance sulforaphane production indirectly by supporting glutathione levels. <br /> <br />+ + + +<br /><br />On the question of can you combine bacopa with broccoli, Chat GPT tells us ...<br /><br />Yes, it is generally safe to combine bacopa (Bacopa monnieri) with broccoli. Bacopa is an herb traditionally used in Ayurvedic medicine to support cognitive function, memory, and overall brain health. Broccoli, on the other hand, is a cruciferous vegetable that is rich in nutrients, including vitamins, minerals, and phytochemicals, known for their potential health benefits.<br /><br />Both bacopa and broccoli offer different compounds that can be beneficial to overall health, and there is no known interaction or contraindication between them. In fact, combining different nutrient-rich foods and supplements can often provide a more diverse range of health-promoting compounds and enhance overall nutritional intake.<br /><br />Bacopa contains active compounds called bacosides, which are believed to contribute to its cognitive and neuroprotective effects. Broccoli, on the other hand, is rich in various antioxidants, vitamins (such as vitamin C and vitamin K), minerals (such as potassium and calcium), and phytochemicals (such as sulforaphane), which have been associated with anti-inflammatory and anticancer properties.<br /><br />By including both bacopa and broccoli in your diet, you can potentially benefit from the unique compounds present in each. However, it's important to note that individual responses to supplements and dietary choices may vary, and it's always a good idea to consult with a healthcare professional or a registered dietitian before making any significant changes to your diet or adding new supplements, especially if you have underlying health conditions or are taking medications.<br /><br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-71509304283480514662023-06-27T02:34:52.427+02:002023-06-27T02:34:52.427+02:00Hello Peter, it's great to see you released yo...Hello Peter, it's great to see you released your book, I wanted to ask, can Baccopa and Sulforaphane be taken toghether?Lisa https://www.blogger.com/profile/00797983091361495962noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-40812672335202789472023-05-31T08:46:57.240+02:002023-05-31T08:46:57.240+02:00SO CAN USE SFN AFTER DINNER AND NAC MORNING?SO CAN USE SFN AFTER DINNER AND NAC MORNING?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-50988337764301124072023-05-30T13:58:13.152+02:002023-05-30T13:58:13.152+02:00There is no right dose, because it depends on your...There is no right dose, because it depends on your gut bacteria, some of which produce myrosinase and how good/reliable the supplement is. As I mention above the "benefit" may not even come from SFN.<br /><br />If one capsule has no effect then try two.<br /><br />Some people see impressive effects and others see none. You just make trials to see what works.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-34416599628156127212023-05-30T11:43:56.207+02:002023-05-30T11:43:56.207+02:00Is it the right dose of Sulforaphane supplement Ja...Is it the right dose of Sulforaphane supplement Jarrow broccomax one capsule for 3.3 years old kid weighs 12.6 kg. Please let me know...supplement details say it yields 8 mg of sulforaphane<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-8825937626615071412023-05-30T09:58:32.804+02:002023-05-30T09:58:32.804+02:00Sulforaphane is a hormetic antioxidant, which mean...Sulforaphane is a hormetic antioxidant, which means that depending on the dose it can be either pro-oxidant or anti-oxidant. In the research they can block some health benefits caused by the pro-oxidant effect by extinguishing it with NAC. <br />NAC is an antioxidant both as itself and in being a precursor to GSH, the body’s own antioxidant. Sulforaphane can activate Nrf2, which serves as a switch to turn on genes involved in defending against oxidative stress. It is unclear whether this results from the pro-oxidant effect, if it did then this would be blocked by taking NAC. This is what Christine (above) is telling you, NAC can block SFN.<br /><br />Broccoli and other cruciferous vegetables are extremely healthy. For example, they produce Indole-3-carbinol (I3C) which has numerous health benefits and is well documented in the research.<br /><br />Under certain circumstances, when you eat broccoli in the presence of an enzyme called myrosinase, a chemical reaction occurs that produce sulforaphane, which is a very unstable compound at room temperature.<br /><br />Numerous accounts confirm the benefit of NAC therapy in autism, first trialled at Stanford University.<br /><br />Trials at Johns Hopkins University showed that a deep-frozen product made from broccoli sprouts and Daikon, that does produce sulforaphane has anti-cancer benefits and has a benefit in autism.<br /><br />A group in the UK have developed a modified version of sulforaphane that is stable at room temperature and I spoke with them several years ago regarding autism.<br /><br />In some people (my son included, many years ago) when taking broccoli powder claiming to produce sulforaphane, there was an effect within about 20 minutes. There was euphoria and then there was an increase in verbalization, not complex speech like can happen with calcium folinate. He would walk along the pavement naming all the things he was walking past (dog, car tree, house etc). All this happened while taking 2,400 mg a day of NAC, to control stereotypy/OCD. Was this effect caused by SFN? Christine would say not. But this is an effect that many parents of young children with severe autism might be very happy with (indeed, mild euphoria for them too).<br /><br />My suggestion is always to make trials of new drugs and supplements one by one and keep notes. Rely mainly for feedback from family or therapists who see you child regularly and do not know that you have started a new intervention. If the therapist/teacher comes up to you and asks what has happened to you child, why is he talking so much, then you know that there is a genuine effect.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-79876217378741876502023-05-30T09:16:52.550+02:002023-05-30T09:16:52.550+02:00Yes I ll do it thank youYes I ll do it thank youDivyanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-68179464685549138852023-05-29T23:31:50.585+02:002023-05-29T23:31:50.585+02:00Sulforaphane (SFN) and NAC do NOT do the same thin...Sulforaphane (SFN) and NAC do NOT do the same thing. SFN has multiple actions but the biggest issue is that NAC stops SFN from performing most of its functions. To take them together only wastes the SFN. ‘Antioxidant’ is not the main focus of SFN. A diet high in non-starchy vegetables is an essential part of therapy. Can you include vegetable juices to increase veg intake? Carrot, Celery, Ginger, Whole lemon and Granny Smith apple is a good combination that tastes nice because carrots and sweet and the apple softens the flavor,Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-46547015070831314502023-05-29T13:44:25.259+02:002023-05-29T13:44:25.259+02:00The thing is we have been following Nemechek proto...The thing is we have been following Nemechek protocol for more than 6 months. He is nonverbal.<br />His stimming hyperactivity repetitive sterotype behaviours are still the same.<br />His cognitive skills improved credit to fish oil.<br />Last month he caught up with covid and hospitalized for four days with antibiotics paracetamol IVs..<br />After discharging all his ASD symptoms got worsen in a bad way. Vocal stimming hand flapping hyperness jumping running laughing repetitive behaviours got over roof top except for his memory skills which is intact.<br />He knows numbers upto 100, alphabets, shapes,vegetables,fruits etc...<br />His sitting tolerance was 20 mins before but now he can't sit even for a minute for lessons.<br />His hyperactivity and stimming prevents him from learning anything.<br />He followed two word commands previously now he doesn't even bothered to listen always jumping here and there.<br />Certainly evoo,inulin,fish oil didn't help to improve his ASD symptoms. <br />His vitamin D is low and B12 is marginal. <br />I'm supplementing him vitamin D and K for three weeks now.<br />I don't know his autism is classic or regressed.<br />I was diagnosed with symphysis pubis dysfunction during pregnancy. I was stressed with pain for the whole time.<br />Caught up with viral fever and hospitalised two weeks before my c-section.<br />I don't know whether it had any impact on the baby or not.<br />He was very normal baby his eye-contact was perfect had few words but he lost it..his stimming hyperactivity came along when he was 16 or 18 months old.<br />After giving him therapy he got back his eye-contact.<br />So far no improvement in his ASD symptoms<br />While researching papers relating autism I found this blog which is an eye opener.<br />He never had constipation or diarrhoea problems before and after inulin.. so I don't know whether he have gut issues or not.. he is on casein free and gluten free diet even before he got diagnosed with ASD.. he is a picky eater..<br />Vitamin D & K drops so far it's been 3 weeks no improvement in his ASD behaviours<br />broccomax day 6.. may be I should wait for weeks as suggested.<br />If Sulforaphane and NAC does the same purpose antioxidant why can't both taken at same time.<br />His OCD behaviours and stimming needs immediate attention if NAC helps it then can I stop Sulforaphane and give NAC instead.<br />Please guide...<br />Divya<br />Divyanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-12921261024516901122023-05-29T10:08:02.388+02:002023-05-29T10:08:02.388+02:00Keep going with Broccomax for another couple of we...Keep going with Broccomax for another couple of weeks and then decide if there is a benefit. Some effects can take a month to appear.<br /><br />Then stop Broccomax and make your trial of NAC. Then assess the benefit or otherwise of NAC.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-41379133974263042622023-05-28T23:57:57.455+02:002023-05-28T23:57:57.455+02:00You should not give NAC with any Sulforaphane-yiel...You should not give NAC with any Sulforaphane-yielding supplement. One week is not long enough to determine anything - you don’t say what you are looking to achieve, No supplement is a magic bullet and should always be used in conjunction with a whole food mixed diet, free of processed items, as far as is possible.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-70275097366800587762023-05-28T17:07:21.396+02:002023-05-28T17:07:21.396+02:00Hi Peter
I have started giving my son one capsule ...Hi Peter<br />I have started giving my son one capsule of broccomax for a week now.. he is 3.3 years old..NAC ll arrive in a couple of days.. I don't find any big gains with broccomax yet he is a bit hyper more.. is it right to add NAC with broccomax please suggest..<br />DivyaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-23033691920801312152023-04-15T05:41:28.763+02:002023-04-15T05:41:28.763+02:00Cell-Logic (Australia) produces cost-effective hig...Cell-Logic (Australia) produces cost-effective high sulforaphane-yielding EnduraCell BioActive as capsules and EnduraCell powder. Each gram of powder yields 15 mg sulforaphane. See our website for technical details. Www.cell-logic.com.au. We supply the US via www.cell-logic-USA.com Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-57347646740869421262023-04-13T20:33:48.071+02:002023-04-13T20:33:48.071+02:00Thank you so much Thank you so much Sudhakar Vankamamidinoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-31560863168900028072023-04-13T09:58:26.917+02:002023-04-13T09:58:26.917+02:00The company went broke.
There are now plenty of b...The company went broke.<br /><br />There are now plenty of broccoli supplements claiming to make Sulforaphane. Some people buy Broccomax via iHerb. There are some expensive products like Avmacol.<br /><br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-11929736285682515642023-04-12T21:43:25.091+02:002023-04-12T21:43:25.091+02:00Dear Peter, seems this http://www.supersprout.com....Dear Peter, seems this http://www.supersprout.com.au/ Australian source of broccoli sprouts is broken, can you please share working link. Thanks Sudhakar Sudhakar Vankamamidinoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-42191327774984277622019-11-13T17:05:32.870+01:002019-11-13T17:05:32.870+01:00Dear All, especially Christina & Peter
Do you ...Dear All, especially Christina & Peter<br />Do you have any idea how can I order these best quality brands of broccoli sprouts in Poland, or in EU? I tried many eshops including Cell-Logic, SuperSprout/AUS and Avamcol/Nutramaxstore but none of them ships to Poland/EU. Would be extremely grateful if you can help. Thanks !<br /><a href="http://healthhide.com/" rel="nofollow">approximately inflammation</a>aslamhttps://www.blogger.com/profile/10314849361481441880noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-87835036114011934002019-08-10T22:03:28.310+02:002019-08-10T22:03:28.310+02:00I've had no problem with getting Cell-Logic or...I've had no problem with getting Cell-Logic or Supersprout deliver to EU, it just takes a lot of time. Last time customs had my package for one month.<br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-91138634629524855902019-08-10T19:14:13.758+02:002019-08-10T19:14:13.758+02:00Dear All, especially Christina & Peter
Do you ...Dear All, especially Christina & Peter<br />Do you have any idea how can I order these best quality brands of broccoli sprouts in Poland, or in EU? I tried many eshops including Cell-Logic, SuperSprout/AUS and Avamcol/Nutramaxstore but none of them ships to Poland/EU. Would be extremely grateful if you can help. Thanks !Leszek Silkowskihttps://www.blogger.com/profile/12477632133145882581noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-20598088544308648372019-05-22T04:46:46.785+02:002019-05-22T04:46:46.785+02:00Thank you, I will give it a go.Thank you, I will give it a go.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-6218677955848940232019-05-21T09:59:29.716+02:002019-05-21T09:59:29.716+02:00Both NAC and broccoli sprouts have multiple modes ...Both NAC and broccoli sprouts have multiple modes of action.<br /><br />We have one commenter on this blog who sells broccoli sprouts and she highlights the research showing that some effects of sulforaphane are reduced by NAC in some models. <br /><br />Generally speaking, antioxidants may be helpful in older people to minimize cancers starting. However once a cancer is established, antioxidants can be harmful because cancer cells are vulnerable to oxidative stress, and so by reducing oxidative stress you may encourage them to grow faster. This is of course a sweeping generalization.<br /><br />I found in my n=1 case of autism, while already taking NAC, that the addition of broccoli sprouts had a prominent effect within 30 minutes. This may not have been sulforaphane, but it was from the broccoli.<br /><br />I use NAC throughout the day and so I do not have a NAC free time to give broccoli. But I think you can safely experiment with this at home. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.com